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PAB35843 NUDT15 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35843
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human

库存 800 件

PAB35843 NUDT15 Polyclonal Antibody

320.00元

Catalog : PAB35843
Application : WB,IHC,ELISA
Reactivity : Human
Product Information


Product name

NUDT15 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human NUDT15

Calculated molecular weight

18kDa

Observed molecular weight 

19kDa

Swiss Prot

Q9NV35

Gene ID (NCBI)

55270

Alternative Names

MTH2;NUDT15D


Application Notes


 

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:100

 

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Western blot analysis of extracts of various cell lines, using NUDT15 antibody.

Immunohistochemistry of paraffin-embedded human liver using NUDT15 antibody.

Immunohistochemistry of paraffin-embedded human stomach using NUDT15 antibody.

    

Background

   

This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. 

                                                                                             

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.