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PAB35835 MDC1 Polyclonal Antibody

价格:    320.00元

  • Catalog:    PAB35835
  • Application:    WB,IHC,ELISA
  • Reactivity:    Human

库存 800 件

PAB35835 MDC1 Polyclonal Antibody

320.00元

Catalog : PAB35835
Application : WB,IHC,ELISA
Reactivity : Human
Product Information


Product name

MDC1 Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,ELISA

Species reactivity

Human

Host Species

Rabbit

Purity

Affinity purification


Immunogen Information


Immunogen

Recombinant protein of human MDC1

Calculated molecular weight

116kDa/195kDa/197kDa/226kDa

Observed molecular weight 

270kDa

Swiss Prot

Q14676

Gene ID (NCBI)

9656

Alternative Names

NFBD1


Application Notes


     

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:100 - 1:200

 

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Western blot analysis of extracts of various cell lines, using MDC1 antibody.

Immunohistochemistry of paraffin-embedded human lung cancer using MDC1 antibody.

Immunohistochemistry of paraffin-embedded human colon carcinoma using MDC1 antibody.

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Immunohistochemistry of paraffin-embedded human prostate using MDC1 antibody.

Immunohistochemistry of paraffin-embedded human prostate cancer using MDC1 antibody.

Immunohistochemistry of paraffin-embedded human esophagus using MDC1 antibody.


Background

   

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

                                                                                              

Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.