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PAB39944 APP Polyclonal Antibody

价格:    440.00元

  • Catalog:    PAB39944
  • Application:    WB,IHC,IF,ELISA
  • Reactivity:    Human,Mouse,Rat

库存 400 件

PAB39944 APP Polyclonal Antibody

440.00元

Catalog : PAB39944
Application : WB,IHC,IF,ELISA
Reactivity : Human,Mouse,Rat
Product Information

 

Product name

APP Polyclonal Antibody

Isotype

IgG

Form

Lyophilized or Liquid

Tested applications

WB,IHC,IF,ELISA

Species reactivity

Human,Mouse,Rat

Host Species

Rabbit

Purity

Affinity purification

Immunogen Information


Immunogen

A synthetic peptide of human APP

Calculated molecular weight

34kDa/72-86kDa

Observed molecular weight 

110kDa

Swiss Prot

P05067

Gene ID (NCBI)

351

Alternative Names

APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; preA4; amyloid beta A4 protein

 

Application Notes


The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

WB

1:500 - 1:2000

IHC

1:50 - 1:200

IF

1:50 - 1:200

 

   图片关键词   图片关键词  图片关键词                   

Western blot analysis of extracts of various cell lines, using APP antibody.

 Immunohistochemistry of paraffin-embedded

 rat brain using APP antibody.

Immunohistochemistry of paraffin-embedded human colon using APP antibody

图片关键词   图片关键词   图片关键词                                                                     

Immunohistochemistry of paraffin-embedded human colon carcinoma using APP antibody

  Immunohistochemistry of

  paraffin-embedded mouse cerebellum

  using APP antibody.

Immunofluorescence analysis of HeLa cells using APP antibody


Background


This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.



Storage


Storage instructions

Store at -20. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.